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Subchapter 7. General Industry Safety Orders
Group 16. Control of Hazardous Substances
Article 110. Regulated Carcinogens

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§5215. 4,4'-Methylenebis(2-Chloroaniline), Appendix B

Appendix B
Supplemental Medical Information
(1) When required tests under Section 5215(k)(2) reveal abnormalities, the tests should be repeated as soon as practicable within 30 days. If the tests remain abnormal, consideration should be given to withdrawing the employee from contact with 4,4′-methylenebis(2-chloroaniline) while a more comprehensive examination is made.
(2) Additional tests that may be useful;
(A) Pulmonary system
1. Sputum cytology
2. Bronchoscopy with bronchial washings for cytology and tissue biopsy.
3. Computerized axial tomography with or without use of a contrast medium.
(B) Liver
1. Liver scan
2. Percutaneous liver biopsy
3. Hepatic angiography
(C) Urinary system
1. Urine cytology, 24-hour specimen
2. Blood urea nitrogen (BUN)
3. Serum creatinine
4. Creatinine clearance
5. Radioactive renogram
6. Intravenous pyelogram (IVP)
7. Cystoscopy with retrograde pyelogram and/or urinary bladder biopsy, as indicated.
8. Percutaneous renal biopsy.
(D) Breasts
1. Mammography
2. Breasts biopsy
(3) Known toxicity of 4,4′-methylenebis(2-chloroaniline)
(A) Pulmonary carcinoma*
(B) Malignant tumors of the liver*
(C) Carcinoma of the breast*
(D) Carcinoma of the urinary bladder*
(E) Kidney irritation
(F) Methemoglobinemia*
*Observed in experimental animals only
(4) Routes of absorption
(A) Skin (primary)
(B) Inhalation (secondary)
(C) Ingestion (minor)
Note: Authority cited: Sections 142.3, 9020, 9030 and 9040, Labor Code. Reference: Sections 142.3, 9004(d), 9009, 9020, 9030, 9031 and 9040, Labor Code.
1. New section and Appendices A-C filed 5-25-79; effective thirtieth day thereafter (Register 79, No. 21).
2. Amendment of subsection (m) filed 3-20-81; effective thirtieth day thereafter (Register 81, No. 12).
3. Editorial correction of subsection (b) filed 3-3-83 (Register 83, No. 10).
4. Change without regulatory effect amending definition of Chief in subsection (b) filed 3-4-92 pursuant to section 100, title 1, California Code of Regulations (Register 92, No. 19).
5. Amendment of subsection (n), repealer of subsections (n)(1)-(3) and amendment of Note filed 7-6-99; operative 8-5-99 (Register 99, No. 28).
6. Change without regulatory effect providing more legible illustration within Appendix A filed 3-2-2009 pursuant to section 100, title 1, California Code of Regulations (Register 2009, No. 10).
7. Amendment filed 5-5-2014; operative 5-6-2014 pursuant to Government Code section 11343.4(b)(3) (Register 2014, No. 19).
8. Editorial correction removing duplicate subsection (j) (Register 2014, No. 31).
9. Editorial correction of subsections (d)(3)(A) and (d)(3)(B) (Register 2016, No. 35).

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